Quantitative Analysis of the Iris Surface Smoothness by Anterior Segment Optical Coherence Tomography in Fuchs Uveitis
Mohamad Zarei1 *, Hamid Riazi-Esfahani1 , Elias Khalili Pour1 , Nazanin Ebrahimiadib1
- Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
Abstract: To demonstrate the value of “smoothness index (SI)” as a novel tool for quantitative analysis of
iris surface findings in unilateral Fuchs’ uveitis (FU).
Methods: Both phakic eyes from patients with unilateral FU as well as healthy control subjects underwent
anterior segment optical coherence tomography (AS-OCT). The ImageJ software was used for calculating
the SI.
Results: Forty eyes from 20 patients with unilateral FU and 40 eyes from 20 healthy subjects were
enrolled. In FU eyes, mean overall SI (0.876 ± 0.030) was significantly higher than fellow control eyes
(0.841 ± 0.041) (p = .001). Mean inter-eye difference for overall SI in the FU patients (0.037 ± 0.030) was
significantly larger than the healthy control subjects (0.018 ± 0.014) (p = .033).
Conclusion: Iris “smoothness index” can be used to quantitatively assess iris surface smoothness and may
facilitate the diagnosis of subtle iris atrophic changes in eyes affected by FU especially in the absence of
heterochromia.
