The Efficacy of Topical Interferon Alpha-2b in Refractory Limbal Vernal Keratoconjunctivitis: A case report
Mitra Akbari1 *
- Eye Research Center, School of Medicine, Guilan Univercity of Mrdical Science, Rasht, Iran
Abstract: to presented the Efficacy of topical Interferon Alpha-2b in refractory limbal vernal keratoconjunctivitis.
Methods: Case report
Results: A 20-year-old man was referred to our cornea clinic with the chief complaints of itching
and photophobia in eyes and foreign body sensation, redness, and ptosis in a both eyes. He had a 10-year
history of gradually enlarging limbal gelatinous masses on both eyes, which according to the other signs and
impression cytology (IC) was diagnosed as a VKC. As the disease in his left eye was more severe and
persistent with maximum topical steroid usage, we started the topical IFN-∝2b eye drops, that a rapid
therapeutic response was observed. After three months of using the topical IFN-∝2b all ocular surface
inflammation and other symptoms rapidly disappeared and we continued this drug till another 3 months, at
12-months follow-up, there was no recurrence of the limbal papillary hypertrophic lesions and other signs
and symptoms of VKC.
Conclusion: In a refractory VKC, topical IFN-∝2b can be used and enhance remission in such
complex cases and can resolve patients complains rapidly.
