Alterations in Choroidal Vascular Parameters Following Pan-retinal Photocoagulation Using Enhanced-Depth Imaging Optical Coherence Tomography

Hamid Riazi Esfahani1 *, Ahmad Mirshahi1 , Elias Khalili Pour1 , Kaveh Fadakar1 , Reza Mirshahi2 , Nazanin Ebrahimiadib1 , Fariba Ghassemi1 , Hassan Khojasteh1 , Fatemeh Bazvand1 , Hooshang Faghihi1

  1. Retina Service, Farabi Eye Hospital, Tehran University Of Medical Sciences, Tehran, Iran
  2. Eye Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran

Abstract: To investigate the alteration of choroid in patients with very severe non-proliferative diabetic retinopathy (NPDR) or early proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP).

Methods: Thirty-nine eyes of 21 patients with very severe NPDR and early PDR were recruited. Enhanced-depth imaging optical coherence tomography at baseline, 1, and 6 months after PRP was employed to measure choroidal parameters including total choroidal area (TCA) and choroidal vascular index (CVI) using a public domain image J software. Binarization and segmentation of OCT images were performed using the protocol described by Sonoda et al .

Results: In eyes with very severe NPDR a non-significant decrease in total choroidal area happened at month 1, followed by a significant increase at month 6 (539 ± 131 µm2 at baseline, 502 ± 134 µm2 at month 1, 598 ± 168 µm2 at month 6 ; P=0.003). An increase in CVI at month 1 was followed by a decrease at month 6 (68.25 ± 3.05 at baseline, 69.74 ± 3.62 at month 1, 67.84 ± 1.77 at month 6; P<0.001). A reverse pattern was observed in eyes with PDR, which was a non-significant increase in total choroidal area at month 1 followed by a decrease at month 6 (497 ± 95 µm2 at baseline, 514 ± 133 µm2 at month 1, 425 ± 95 µm2 at month 6; P=0.011). CVI decreased at month 1 and remained relatively stable at month 6 (69.34 ± 3.11 at baseline, 68.33 ± 3.41 at month 1, 68.50 ± 5.04 at month 6; P=0.023). Alteration of choroidal thickness was not statistically significant in both groups.

Conclusion: Eyes with very severe NPDR and early PDR exhibit a reverse pattern regarding choroidal indices after PRP.





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