Optic Nerve Head Parameters and Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Coronavirus Disease 2019

Mojtaba Abrishami1 *, Ramin Daneshvar1 , Zahra Emamverdian1 , Fariba Tohidinezhad2

  1. Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  2. Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract: To quantify the optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Coronavirus Disease 2019 (COVID-19) and compare the measurements with a healthy control group.

Methods: In a comparative cross-sectional, observational study patients recovered from COVID-19 between May 3, 2020, and May 16, 2020, included in this study. All included subjects had confirmed the diagnosis of COVID-19 by a positive reverse transcription-polymerase chain reaction of a nasopharyngeal sample. ONH and peripapillary RNFL thickness were evaluated using spectral-domain optical coherence tomography in patients with a history of COVID-19 and at least 2 weeks after recovery from the systemic disease and compared with age-matched normal controls.

Results: Thirty COVID-19 patients (mean age: 40.1 ± 9.4 years; 16 male) along with 60 age- and gender-matched healthy controls (mean age: 39.4 ± 7.9 years; 32 male) were studied. Mean average peripapillary RNFL thickness was 105.0 ± 16.3 µm in the COVID patients compared to 99.0 ± 9.0 µm in the controls (p=0.31). Peripapillary RNFL thicknesses in different segments showed to be higher in patients with a history of COVID-19 than normal controls; however, this did not reach statistical significance. Similarly, ONH parameters were not different in both groups.

Conclusion: Patients who had recovered from COVID-19 displayed unremarkable alterations in the peripapillary RNFL thickness.





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