Pachychoroid spectrum: natural course and Outcome of Different Treatment Regimen

Nazanin Ebrahimiadib1 *, Mohammadreza Mehrabi Bahar1 , Hamid Riazi-esfahani1 , Elias Khalili Pour1 , Fariba Ghassemi1 , Ahmad Mirshahi1 , Alireza Mahmoudi1 , Kavevh Fadakar1 , Alireza Lashay1 , Houshang Faghihi1

  1. TUMS

Abstract: To study the alterations in choroidal parameters in eyes with the pachychoroid spectrum.

Methods: Design: Unicenter retrospective cohort study. All patients with subfoveal choroidal thicknes of more than 300 μm or dilated vessels in Haller layer and a compressed choriocapillaris layer were included in this study. Imaging of EDI-OCT and OCT-A were investigated. Choroidal features, such as subfoveal choroidal thickness (SFCT), total choroidal area (TCA), luminal choroidal area (LCA), and stromal choroidal area (SCA) were analyzed. Choroidal vascularity index (CVI) was calculated in all study eyes at baseline and follow up visits. Further study were performed on characteristics of branching vascular network (BVN) in OCT-A scans.

Results: A total of 58 eyes from 29 subjects; 42 eyes (29 patients) with pachychoroid spectrum and 16 fellow eyes with uncomplicated pachychoroid were included. Twenty two (78.6%) patients were male. Mean TCA was 1.15±0.34 mm2 and 1.12±0.33 mm2, mean LCA was 0.82 ± 0.23 mm2 and 0.81±0.24 mm2, mean SFCT was 392.93 ± 101.67 μ m (range, 238-649 μm) and 388.91 ± 105.86 μm (range, 198-633 μm), mean CVI was 71.32 ± 2.96% (range, 65.74–77.55%) and 72.29 ± 3.33% (range, 64.48–80.08%) at baseline and final follow up visit, respectively. The minimum follow up time was 5 months. The mean flow area in the choriocapillaris layer, using enface OCT-A, was 4.38 ± 0.50 mm2(range, 3.17-5.12) and 4.48 ± 0.41 mm2(range, 2.72-5.14) at baseline and final visit, respectively.

Conclusion: Our study showed that in all pachychoroid groups, a nonsignificant increase in CVI occurs, regardless of receiving treatment or not. Further studies need to clarify the choroidal alteration in time in pachychoroid spectrum disease.





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