Association of Carbamazepine-induced Ocular Stevens -Johnson Syndrome and Human Leukocyte Antigen -B*15:02 in Iranian Population

Acieh Es'haghi1 *, Hossein Aghaei2 , Yasaman Hadi2 , Golnaz Khakpour3 , Parya Abdolalizadeh3 , Maryam Ghandali3

  1. Department of Ophthalmology, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran ,Iran.
  2. Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  3. Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Abstract: HLA-B alleles have been shown to be associated with hypersensitivity reactions in patients who are under treatment with carbamazepine. The aim of this study was to investigate the association between the HLA-B*15:02 and carbamazepine-induced ocular Stevens-Johnson syndrome (SJS) in Iran.

Methods: 13 patients with carbamazepine induced ocular SJS (case group) and 10 carbamazepine-tolerant patients (control group) were included in the study. HLA-A, HLA-B and HLA-DR genotyping was performed by polymerase chain reaction (PCR) assays following by hybridization with specific oligonucleotide probes.

Results: The median age was 41.0 years and 35.5 years in cases and controls respectively. 76.9% of the cases and 60.0% of controls were female. Presence of HLA-A*33:01 (P=0.027) and HLA-B*15:02 (P=0.027) were significantly more in carbamazepine users diagnosed as ocular SJS than control group.

Conclusion: Presence of HLA-B*15:02 and HLA-A*33:01 seems to be effective predictive markers for carbamazepine-induced ocular SJS in Iranian patients.





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