Peripapillary Capillary Network in Methanol Toxic Optic Neuropathy
Kiana Hassanpour1 *, Negin Mohammadi2 , Hamideh Sabbaghi1 , Mohammad Pakravan 3
- Ophthalmic Research Center, Research institute for Ophthalmology and vision Scinece, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences
- Ophthalmic Epidemiology Research Center, Research institute for Ophthalmology and vision Scinece, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: we present the optical coherence tomography angiography (OCT-A) findings of the radial peripapillary capillary (RPC) network an individual with severe bilateral methanol-induced toxic optic neuropathy (MTON)
Methods: A 35-year-old man with severe bilateral MTON referred to neuro-ophthalmology clinic of Labbafinejad Medical Center. The Angio Vue OCT 3D set of 4.5 mm X 4.5 mm was used to measure disc and peripapillary vessel density. Two patients were examined with the same protocol as controls. One of the controls was age and sex-matched healthy individual and the second one was a known retinitis pigmentosa patient
Results: RPC density was 37.7 in MTON, 46.9 in RP patient and 54.7 in healthy control.
Conclusion: We found the reduction in the RPC vessel density in MTON compared to a healthy individual and also a patient with optic pallor secondary to RP. The possible mechanism explaining the reduced vascular density can be the loss of capillaries secondary to the loss of nerve fibers and ganglion cells. Moreover, MTON can be considered an optic neuropathy with direct mitochondrial damage of endothelial cells of capillaries
