Isolates and Antibiotic Resistance of Culture-Proven Endophthalmitis Cases: 8 years review
Sayyed amirpooya Alemzadeh1 *, Khalil Ghasemi Falavarjani 1 , Pasha Anvari1 , Parsa Panahi2 , Nasser Mirzakouchaki Borujeni2
- Eye Research Center, The Five Senses Institute Rassoul Akram Hospital , Iran University of Medical Sciences, Tehran, Iran
- Student Research Committee, school of medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract: To evaluate the spectrum of organisms causing endophthalmitis and their resistance pattern to standard antimicrobial agents.
Methods: Medical records of culture-positive eyes managed at the tertiary hospital for endophthalmitis from 2012 to 2019 were reviewed. Specimens were obtained during pars plana vitrectomy or vitreous tap
Results: Fifty-nine isolates including 31 (52.5%) gram-positive organisms, 14 gram-negative organisms (23.7%), and 4 (6.7%) fungus were studied. The most common settings were acute post-cataract surgery in 30 of 59 (50.8%) The most common organism identified was Streptococcus pneumonia in 11 eyes (18.6%). Among the antibiotics available for intravitreal injection, the least antibiotic resistance was for vancomycin in gram-positive organisms and amikacin and ceftazidime in gram-negative isolates.
Conclusion: Gram-positive isolates were the most prevalent organisms; however, a high
isolation rate for gram-negative and fungal organisms was obtained. Considering that no single antibiotic
provides coverage for all of the organisms, a combination therapy using vancomycin/amikacin
or vancomycin/ceftazidime seems to be useful as the initial empiric treatment of suspected
bacterial endophthalmitis
