The Effect of Meibomian Gland Dysfunction Treatment on Sleep Quality.
Samira Hassanzadeh1 *, Siamak Zarei-Ghanavati2 , Abbas Azimi Khorasani3 , Asieh Ehsaei4
- M.Sc., Ph.D. Student in Optometry, Student Research Committee, Department of Optometry, Paramedical College, Mashhad University of Medical Sciences, Mashhad, Iran.
- MD., Associate Professor of Ophthalmology, Eye Research Center, Department of Ophthalmology, Mashhad University of Medical Sciences, Mashhad, Iran. Email: siamakzarei@gmail.com.
- Ph.D., Professor of Optometry, Refractive Error Research Center, Paramedical College, Department of Optometry, Mashhad University of Medical Sciences, Mashhad, Iran. Email: AzimiA@mums.ac.ir.
- Ph.D., Associate Professor of Optometry, Refractive Error Research Center, Paramedical College, Department of Optometry, Mashhad University of Medical Sciences, Mashhad, Iran. Email: EhsaeiA@mums.ac.ir
Abstract: To assess the therapeutic efficacy of a five-flash intense pulsed light (IPL) technique in combination with conventional treatment for meibomian gland dysfunction (MGD) on sleep quality of the patients.
Methods: Fifty symptomatic participants with a clinical diagnosis of MGD were enrolled in this study. participants underwent three sessions of IPL therapy. There was a two- week interval between IPL sessions 1 and 2, and one month between sessions 2 and 3. Treatment was supplemented with conventional home-based therapy (including lid hygiene, warm compress, eyelid massage, and lid margin scrub) for MGD. Dry eye symptomatology, tear film and ocular surface parameters were evaluated at baseline (day 0), day 15, 45, and 75. Sleep quality was assessed before and after the study using Pittsburgh sleep quality index (PSQI).
Results: PSQI components were improved significantly at day 75 in comparison with the baseline (p<0.05). Ocular Surface Disease Index (OSDI) score, non-invasive keratograph tear break up time (NIKBUT), fluorescein tear break-up time, meibomian gland expressibility, meibum quality and tear osmolarity were improved at follow up visits (p<0.05). Younger patients showed more improvement in NIKBUT, sleep quality and duration (p=0.024, p=0.047, p=0.008). Sleep latency decreased with increased NIKBUT and FTBUT and decreased OSDI score (p=0.001, p=0.005 and p=0.041).
Conclusion: Three sessions of IPL therapy in combination with supplementary conventional home- based therapy is effective on sleep quality of patients with MGD.
